NANA10 Studie mit 128 Patienten (engl.)

Publikation auf Researachgate

Kurzbeschreibung (deutsch):

  • In einer retrospektiven, praxisbasierten Follow-up-Analyse wurden 128 Patientinnen und Patienten mit chronischen Gesundheitsproblemen und einer zonulinbezogenen klinischen Fragestellung ausgewertet.
  • Unter einer NANA10-basierten Intervention in Kombination mit einer Vitamin-D-Optimierung sank der Median des fäkalen Zonulinspiegels von 179,5 ng/ml auf 82,7 ng/ml.
  • Der Anteil oberhalb der Referenzgrenze von 131 ng/ml verringerte sich von 59,38 % auf 21,09 %.
  • Gepaarte nichtparametrische Tests, der McNemar-Test, der Friedman-Test sowie ein log-lineares Zeitmodell zeigten konsistent hochsignifikante Abnahmen.
  • Longitudinalanalysen sprechen für eine weitgehend nachhaltige Reduktion;
  • eine Kaplan-Meier-ähnliche Darstellung weist auf eine substanzielle Normalisierung pathologischer Werte über einen Zeitraum von etwa 18 bis 20 Monaten hin.
  • Aufgrund des retrospektiven, unkontrollierten Designs sind die Ergebnisse hypothesengenerierend und sollten in prospektiven kontrollierten Studien überprüft werden.

ENGL. ABSTRACT
www.VitaminDService.de/nana10-engl

zum Journal:
 







Successful Reduction of Fecal Zonulin Levels
Under a NANA10-Based Intervention: A
Retrospective Follow-Up Analysis of 128 Patients
With Four Complementary Longitudinal
Assessments
Author
Dr. med. Raimund von Helden
Verbraucherberatung Privat-Institut VitaminDelta
57368 Lennestadt, Germany
Email: vitamindelta@me.com
Abstract
Background
Zonulin is discussed as a marker of increased intestinal permeability and is frequently associated in
clinical terminology with the concept of “leaky gut.” In a general medical practice, fecal zonulin levels
were measured in patients with chronic health problems and were subsequently reassessed during
follow-up after a NANA10-based intervention combined with optimization of vitamin D status.
Objective
The aim of this retrospective analysis was to summarize the course of fecal zonulin levels in a shared
dataset of 128 patients undergoing a NANA10-based intervention. The analysis combines four
previously separate assessments: the primary before-and-after effect, durability across multiple
measurement time points, observation of a relapse during an interruption of intake, and a Kaplan–
Meier-like presentation of the normalization of pathologically elevated zonulin levels.
Methods
A total of 128 patients from a general medical practice were evaluated. The mean age was 53.7 years,
with a range from 2 to 79 years. Zonulin was measured in stool samples. The intervention consisted of
optimization of vitamin D levels to 50–100 ng/ml and intake of NANA10, a combination of ten natural
dietary supplement components. Further information is available at www.NANA10.de. Laboratory
analysis was performed using an EIA test system from Immundiagnostik AG. Non-exactly quantified
extreme values were coded conservatively for the analysis; for example, values reported as “>800” were
entered as exactly 800 ng/ml, and values reported as “<15” or “<5” were entered as exactly 15 or exactly
5 ng/ml, respectively. For the primary analysis, paired values at time point 1 (Z1) and Z2 were evaluated
in n=128 patients. Additional available longitudinal values up to Z7 were also considered.
This work should explicitly be understood as a retrospective, exploratory, practice-based follow-up
analysis. It does not replace a randomized controlled trial but may serve as a basis for prospective
studies.

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